Product Description
Endurance performance depends heavily on how efficiently your body shifts between burning glucose and fat as fuel sources, and AMPK, a cellular energy-sensing enzyme, is one of the key switches governing that shift. Berberine is one of the most studied plant compounds for its effect on activating AMPK specifically.
Thorne's Berberine provides nutritional support for maintaining healthy cholesterol and blood sugar levels, promoting GI microbial balance, and supporting healthy metabolism.
Activates AMPK, a key cellular energy switch – AMPK plays a central role in how your cells regulate energy use, influencing glucose and lipid metabolism broadly.
A pure, concentrated 200 mg dose – No blended forms or fillers to worry about — just Berberine HCl from Indian Barberry extract, the form used in most of the clinical research behind this compound.
Supports gut microbial balance – Beyond the metabolic angle, berberine is also studied for its effect on maintaining a balanced gut microbial environment.
Berberine works primarily by activating AMPK, your cells' energy-regulating switch, which helps govern how your body uses glucose and fat for fuel. It clears your system fairly quickly, which is why this is dosed multiple times a day instead of once — spreading it out keeps levels steadier than one large dose would.
How to Use Thorne Berberine
Dose: Take 1 capsule two to three times daily, with food, or as recommended by your health-care practitioner.
- Gluten free
- Sport Tested: NSF Certified for Sport®
Supplement Facts
30 Servings
Serving Size: 1 Capsule
Serving Per Container: 60
| Amount Per Serving | ||
|---|---|---|
| % Daily Value* | ||
| Berberine HCl (from Indian Barberry extract) (root) (Berberis aristata) 200mg | ** | |
* Percent Daily Values are based on a 2,000 calorie diet. Your daily values may be higher or lower depending on your calorie needs.
** Daily Value (DV) not established
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Thorne Berberine - 200 mg FAQ's
Everything you need to know about Thorne Berberine - 200 mg.



The athlete angle is AMPK — the same cellular switch that governs how efficiently your body shifts between burning carbs and fat during training. It's also studied for maintaining healthy blood sugar and cholesterol, which matters when you're carrying a heavy training load.
Berberine clears your system fairly quickly, so splitting the 200 mg dose across the day keeps levels more consistent than one large dose would. Take each dose with food for best tolerance.
It's generally well tolerated at this dose when taken with food, though some people notice mild GI effects when they first start. If you're timing doses around workouts, take it with a meal well before training rather than right beforehand.
Thorne doesn't list known interactions with common training supplements for this product. Still, introduce it on its own for a few days before adding it to your full stack, and check with your provider if you're on medication for blood sugar or cholesterol.
Skip it if you're pregnant, nursing, or trying to conceive — Thorne is explicit about that. Also hold off if you have a known sensitivity to any of the listed ingredients, and check with your healthcare provider if you're on blood sugar or cholesterol medication.